Preheat the oven to 350F. Place 6 liners in a muffin pan or spray the pan with cooking spray.
In a bowl, mix the flour, baking soda, baking powder, honey, and oil together. In a measuring cup, measure out 1 cup of blueberries. Using a muddler, smash the blueberries. Combine the smashed blueberries to the bowl and stir.
Place mixture into the cups. Bake for 10-15 minutes, until browned and when you insert a toothpick into the center it comes out clean.
While the cupcakes are cooking in the oven, measure out another cup of blueberries. Smash the blueberries in the measuring cup. Using a strainer, strain the juice from the smashed blueberries, into a bowl. Add 4 oz of cream cheese to the bowl and stir to combine.
Once the cupcakes are done and cooled (if you put the cream cheese frosting when it’s hot, it will melt) frost the cupcakes. Top with your dog’s favorite treat!